4 edition of Na,K-Atpase and Related Cation Pumps found in the catalog.
by New York Academy of Sciences
Written in English
|Contributions||Peter Leth Jorgensen (Editor), Steven J. D. Karlish (Editor), Arvid Bernhard Maunsbach (Editor)|
|The Physical Object|
|Number of Pages||718|
pump [pump] 1. an apparatus for drawing or forcing liquid or gas. 2. to draw or force liquids or gases. blood pump a machine used to propel blood through the tubing of extracorporeal circulation devices. breast pump a pump for taking milk from the breast. calcium pump the mechanism of active transport of calcium (Ca2+) across a membrane, as of the. Na + /K +-ATPase ATPase pump, like H + /K +-ATPase and Ca + /K +-ATPase, is an enzyme which plays the role of pump. It ensures the transmembrane transfer of the cations Na + and K +. Na + /K +-ATPase is located in the cytoplasmic membranes. It consists of .
Abstract. Na + /K +-ATPase (NKA), a transmembrane protein, facilitates active transport of three Na + out of the cell and two K + into the cell with the expense of an ATP. It plays an important role in regulating the ionic homeostasis and maintaining membrane potential. Additionally, NKA plays a crucial role in driving a variety of secondary transport processes such as Na +-dependent glucose Cited by: 4. The Na + /K + ATPase pump is a pump found in the membrane of animal cell which uses the hydrolysis of ATP to pump 3Na + out of the cell and 2K + into the is a primary active transport and belongs to the family of P-type regulates the osmolarity of the cytosol by controlling the solute concentration inside the main function of the N+/K+ ATPase pump is to maintain.
Na + /K +-ATPase (NKA) is an essential cation pump protein responsible for the maintenance of the sodium and potassium gradients across the plasma ly published high-resolution structures revealed amino acids forming the cation binding sites (CBS) in the transmembrane domain and variable position of the domains in the cytoplasmic by: 8. The principal primary active transport system in neurons, the Na/K-ATPase utilizes energy to maintain cation cellular concentrations by extruding Na and accumulating K ions, thus creating an electrical potential across the neuronal cell membrane. It is estimated that 25 to 40% of brain energy utilization may be related to Na/K-ATPase activity.
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Get this from a library. Na, K-ATPase and related cation pumps: structure, function, and regulatory mechanisms. [Peter Leth Jørgensen; Steven J D Karlish; Arvid Bernhard Maunsbach;]. Bartnik, P.C. Facey, in Pharmacognosy, Bioactivity of Cardiac Glycosides. Digitalis glycosides can be defined as allosteric inhibitors of Na +- K +-ATPase, a protein cation pump, which uses the energy derived from the hydrolysis of ATP for active transport of potassium ions inside, and sodium ions outside cells (where K +:Na + is as ).
The therapeutic concentrations of. Get this from a library. Na, K-ATPase and related cation pumps: structure, function, and regulatory mechanisms. [Arvid B Maunsbach; Peter Leth Jørgensen; Steven J. The Na +,K +-ATPase is a P-type (named for its phosphorylated intermediate) pump that exports three Na + ions and imports two K + ions per ATP hydrolysed.
The ion-6 Cited by: Na⁺/K⁺-ATPase (sodium–potassium adenosine triphosphatase, also known as the Na⁺/K⁺ pump or sodium–potassium pump) is an enzyme (an electrogenic transmembrane ATPase) found in the membrane of all animal cells. It performs several functions in cell physiology. The Na + /K +-ATPase enzyme is active (i.e.
it uses energy from ATP).For every ATP molecule that the pump uses, three BRENDA: BRENDA entry. The Na +,K +-ATPase is a P-type (named for its phosphorylated intermediate) pump that exports three Na + ions and imports two K + ions per ATP hydrolysed.
The ion-binding sites are accessible from the extracellular space in the phosphorylated conformation, called E2P, and from the cytoplasm in the dephosphorylated configuration, by: BRAIN Na +, K +-ATPase STRUCTURE. Na +, K +-ATPase is an olygomeric enzyme consisting of α and β subunits, both required for enzyme function (Fig.
(Fig.1). 1).Alpha subunit is the catalytic one which exists in different isoforms: α1, α2, α3, or α4, the latter identified only in testis ().The binding sites for ATP and the inhibitor ouabain as well as ion occlusion occur in α subunit ().Cited by: Recently the molecular structure of the related sar- Na,K-ATPase is the largest protein complex in the family of P-type cation pumps.
The minimum functional unit is a heterodimer of the ﬁ- andﬂ-subunits THE KINETIC MECHANISM OF Na,K-ATPase Extensive studies into the cation transport mechanism and partial reactions, in-File Size: 1MB.
Scott J. Schurman, Steven J. Scheinman, in Genetics of Bone Biology and Skeletal Disease (Second Edition), Role of Kir in Kidney. In the DCT, basolateral Na + /K +-ATPase transports sodium to the interstitium and potassium to the intracellular compartment against chemical teral potassium channels recycle potassium to the interstitium and Kir is the dominant.
extracellular volume and blood pressure. The Na+/K+-ATPase is the receptor of digitalis steroids used to treat heart failure. Na+/K+-ATPase is one of a family of cation pumps, the P-type ATPases, which includes also sarcoplasmic reticulum Ca2+-ATPase, gastric cell membrane H+/K+-ATPase, plasma membrane Ca2+-ATPase, plant cell membrane H+-ATPase.
Na, K-Atpase and Related Cation Pumps: Structure, Function, and Regulatory Mechanisms (Annals of the New York Academy of Sciences) International Conference on Na, K-ATPase and Related Cation Pumps (10th: Helsingr, Denmark).
The Na +/K -ATPase is the receptor of digitalis steroids used to treat heart failure. Na+/K+-ATPase is one of a family of cation pumps, the P-type ATPases, which includes also sarcoplasmic reticulum Ca2+-ATPase, gastric cell membrane H +/K -ATPase, plasma membrane Ca2+-ATPase, plant cell membrane H+-ATPase, heavy metal-dependentFile Size: KB.
Na + /K +-ATPase. Under resting conditions, Na + slowly leaks into the cells and K + leaks out of the cell because of electrochemical driving forces. Whenever an action potential is generated, additional Na + enters the cell and K + leaves the cell. While the number of ions moving across the sarcolemmal membrane in a single action potential is.
Start studying UNIT 1 - KA3: Ion Transport Pumps and the Na/K ATPase. Learn vocabulary, terms, and more with flashcards, games, and other study tools. The primary structures of the catalytic a and glycosylated β subunits are similar to those of the corresponding subunits of Na + /K +-ATPase.
The residues located in the catalytic and cation binding sites have been proposed from the combined results of protein chemical studies and sequence comparisons of P-type cation transporting by: The process of moving sodium and potassium ions across the cell membrance is an active transport process involving the hydrolysis of ATP to provide the necessary energy.
It involves an enzyme referred to as Na + /K + sodium-potassium pump is an important contributer to action potential produced by nerve cells.4/5(2).
to the Na +,K ATPase and Ca2+ATPase33–35, establish ing a larger family of Ptype ATPase ion pumps that work according to common principles as described by. The sodium and potassium gradients across the plasma membrane are used by animal cells for numerous processes, and the range of demands requires that the responsible ion pump, the Na,K-ATPase, can be fine-tuned to the different cellular needs.
Therefore, several isoforms are expressed of each of the three subunits that make a Na,K-ATPase, the alpha, beta and FXYD by: The adenosine triphosphatases (ATPases) are integral membrane proteins that actively exchange ions across cell membranes; the energy required for this process is derived from hydrolysis of one molecule of ATP.
The sodium (Na+), potassium (K+) ATPase (Na+, K+-ATPase) simultaneously extrudes 3 Na+ ions from the intracellular compartment in exchange for 2 K+ ions from the Cited by: Na +, K + -ATPase pumps Na + and K + ions against their concentration gradients for the ions, and produces a convenient driving force for the secondary transport of metabolic substrates such as.
The Na+/K+ pump is found in the membranes of many types of cells. In particular, it plays a very important role in nerve cell membranes.
In order to move the ions (Na+ and K+) againts their gradients, energy is required. This energy is supplied by ATP (adenosine triphosphate).5/5(1).Na + /K +-ATPase is an enzyme found in the plasma is sodium-potassium adenosine triphosphatase, also known as the 'Na + /K + pump', 'sodium-potassium pump', or simply 'sodium pump', for short.
It was first discovered by Jens Christian Skou who won a Nobel Prize in Chemistry in The enzyme moves Na + ions out of the cell and replaces them with K + ions.the role of the na+/k+-atpase pump Na+/K+-ATPase pumps are responsible for establishing Na+ and K+ gradients Active transport against concentration gradients requires energy from the hydrolysis of ATP (Without ATP, no gradients, no electrical signaling).